Anthony J Kettle Selected Research

Hypochlorous Acid (Hypochlorite)

1/2020	Myeloperoxidase inhibition decreases morbidity and oxidative stress in mice with cystic fibrosis-like lung inflammation.
1/2019	Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis.
9/2015	Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis.
7/2014	Oxidation contributes to low glutathione in the airways of children with cystic fibrosis.
10/2009	Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils.
10/2009	Simultaneous determination of reduced glutathione, glutathione disulphide and glutathione sulphonamide in cells and physiological fluids by isotope dilution liquid chromatography-tandem mass spectrometry.
12/2004	Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis.
3/2003	3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome.

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Anthony J Kettle Research Topics

Disease

28	Inflammation (Inflammations) 01/2022 - 12/2004
13	Infections 01/2022 - 03/2003
12	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 12/2004
5	Atherosclerosis 01/2019 - 02/2002
4	Rheumatoid Arthritis 12/2018 - 04/2010
4	Lung Diseases (Lung Disease) 12/2017 - 03/2003
4	Asthma (Bronchial Asthma) 04/2010 - 09/2002
3	Gout 12/2018 - 04/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 04/2011
2	Myeloperoxidase Deficiency 07/2015 - 02/2013
2	Peritonitis 02/2014 - 10/2011
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2022
1	Alzheimer Disease (Alzheimer's Disease) 01/2022
1	Pneumonia (Pneumonitis) 01/2020
1	Septic Shock (Toxic Shock Syndrome) 01/2020
1	Critical Illness (Critically Ill) 01/2020
1	Coinfection 01/2019
1	Insulin Resistance 01/2019
1	Reperfusion Injury 01/2019
1	Pathologic Constriction (Stenosis) 01/2019
1	Rupture 01/2019
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2019
1	Leukemia 01/2018
1	Bronchiectasis 12/2017
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 10/2016
1	Muscular Dystrophies (Muscular Dystrophy) 10/2016
1	Necrosis 10/2016
1	Nephritis 07/2015
1	Glomerulonephritis 07/2015
1	Arteritis 02/2014
1	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2014
1	Neuroblastoma 01/2014
1	Tuberculosis (Tuberculoses) 10/2012
1	Drug-Related Side Effects and Adverse Reactions 10/2012
1	Hyperuricemia 04/2011
1	Pain (Aches) 09/2010

Drug/Important Bio-Agent (IBA)

23	Peroxidase (Myeloperoxidase)IBA 12/2022 - 12/2004
18	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
12	Oxidants (Oxidizing Agents)IBA 01/2019 - 09/2002
8	Hypochlorous Acid (Hypochlorite)IBA 01/2020 - 03/2003
7	Biomarkers (Surrogate Marker)IBA 12/2022 - 03/2003
7	EnzymesIBA 01/2019 - 03/2006
5	Uric Acid (Urate)IBA 12/2018 - 04/2011
4	glutathione sulfonamideIBA 03/2017 - 02/2014
4	Serotonin (5 Hydroxytryptamine)IBA 12/2016 - 12/2009
4	PeroxidasesIBA 07/2014 - 09/2002
3	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2022 - 09/2015
3	CytokinesIBA 01/2019 - 07/2015
3	Free RadicalsIBA 01/2018 - 01/2008
3	AcidsIBA 01/2018 - 09/2002
3	AntioxidantsIBA 12/2017 - 02/2002
3	Glutathione (Reduced Glutathione)IBA 12/2017 - 07/2014
3	AllantoinIBA 03/2017 - 04/2012
3	AminesIBA 09/2015 - 12/2009
3	3-chlorotyrosineIBA 02/2014 - 03/2003
2	thiocyanateIBA 01/2022 - 08/2015
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 07/2015
2	Biological ProductsIBA 01/2019 - 07/2014
2	AlarminsIBA 01/2019 - 01/2019
2	Glutathione Disulfide (GSSG)FDA LinkGeneric 12/2017 - 03/2017
2	Heme (Haem)IBA 11/2012 - 03/2006
2	Superoxides (Superoxide)IBA 04/2011 - 09/2010
2	hypobromous acidIBA 10/2009 - 02/2009
1	Peptides (Polypeptides)IBA 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 01/2022
1	TransferasesIBA 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2020
1	Alanine (L-Alanine)FDA Link 01/2020
1	DisulfidesIBA 01/2019
1	Apolipoproteins E (ApoE)IBA 01/2019
1	Cysteine (L-Cysteine)FDA Link 01/2019
1	Interleukin-33IBA 01/2019
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2019
1	Sulfides (Thioethers)IBA 01/2019
1	CarbohydratesIBA 01/2019
1	Serum AlbuminIBA 12/2018
1	quinone (benzoquinone)IBA 12/2016
1	Sulfhydryl Compounds (Thiols)IBA 10/2016
1	Amino Acids FDA Link 10/2016
1	Taurine FDA Link 10/2016
1	IonsIBA 09/2015
1	MetalsIBA 09/2015
1	Complement System Proteins (Complement)IBA 07/2015
1	pristane (pristan)IBA 07/2015
1	Oxypurinol (Oxipurinol)IBA 11/2014
1	Allopurinol (Remid)FDA LinkGeneric 11/2014
1	LactoperoxidaseIBA 07/2014
1	Horseradish PeroxidaseIBA 07/2014
1	Methionine (L-Methionine)FDA Link 05/2014
1	PlasmalogensIBA 02/2014
1	ChlorineIBA 02/2014
1	Ceruloplasmin (Ferroxidase)IBA 03/2013
1	Isoniazid (Ftivazide)FDA LinkGeneric 10/2012
1	Pharmaceutical PreparationsIBA 10/2012
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2012
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2011
1	EnkephalinsIBA 09/2010
1	Opioid Peptides (Opioid Peptide)IBA 09/2010

Therapy/Procedure

1	Oral Administration 01/2019
1	Therapeutics 07/2014